Journal article
No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis—A Randomized Clinical Trial
TD Kristensen, BH Ebdrup, C Hjorthøj, RCW Mandl, JM Raghava, JRM Jepsen, B Fagerlund, LB Glenthøj, C Wenneberg, K Krakauer, C Pantelis, BY Glenthøj, M Nordentoft
Frontiers in Psychiatry | FRONTIERS MEDIA SA | Published : 2020
Abstract
Background: Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods: In a randomized, clinical trial, UHR individuals aged 18 to 40 years were assigned to treatment as usual (TAU) or TAU plus cognitive remediation for 20 weeks. Cognitive remediation comprised 20 x 2-h sessions of neurocognitive and social-cognitive training. Primary outcome was whole brain fractional anisotropy derived from diffusion weighted imaging, statistically tested as an inter..
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Funding Acknowledgements
The study was funded by The Danish Council for Independent Research (DFF-4004-00314); TrygFoundation (108119); the Mental Health Services in the Capital Region of Denmark; the research fund of the Capital Region of Denmark; the Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS (R155-2013-16337). CP was supported by a NHMRC Senior Principal Research Fellowship (1105825) and by a grant from Lundbeck Foundation (R246-2016-3237).